IV saline in bags manufactured by both Hospira and Baxter contained 1600-8000 microparticles/mL and 4-73 × 10⁶ nanoparticles/mL in solution. When IV immunoglobulin was diluted into the IV saline, 3700-23,000 microparticles/mL and 18-240 × 10⁶ nanoparticles/mL were detected. During processing of the solution through the IV system, in-line filters removed most microparticles. However, there were still 1-21 × 10⁶ nanoparticles/mL in IV saline and 7-83 × 10⁶ nanoparticles/mL in IV immunoglobulin diluted in saline.
Yes, why bother?
With Hospira "saline solution" there was no control group anyway (ha ha).
https://www.researchgate.net/publication/309756855_Microparticles_and_Nanoparticles_Delivered_in_Intravenous_Saline_and_in_an_Intravenous_Solution_of_a_Therapeutic_Antibody_Product
IV saline in bags manufactured by both Hospira and Baxter contained 1600-8000 microparticles/mL and 4-73 × 10⁶ nanoparticles/mL in solution. When IV immunoglobulin was diluted into the IV saline, 3700-23,000 microparticles/mL and 18-240 × 10⁶ nanoparticles/mL were detected. During processing of the solution through the IV system, in-line filters removed most microparticles. However, there were still 1-21 × 10⁶ nanoparticles/mL in IV saline and 7-83 × 10⁶ nanoparticles/mL in IV immunoglobulin diluted in saline.
https://www.fda.gov/safety/recalls-market-withdrawals-safety-alerts/hospira-issues-voluntary-nationwide-recall-one-lot-sterile-water-injection-usp-due-potential
https://www.alltherisks.com/trade-secret